Incidence, clinical characteristics, and associated diseases in patients with immune thrombocytopenia: A nationwide population-based study in Taiwan. Issue 164 (April 2018)

• Record Type: Journal Article
• Authors: Wu, Shu-Ruei; Kuo, Hsiao-Ching; Huang, Wei-Chun; Huang, Yung-Feng; Chiou, Yee-Hsuan; Chang, Yu-Hsiang; Nong, Bao-Ren
• Is Part Of: Thrombosis research. Issue 164(2018)
• Page Start: 90
• Page End: 95
• Publication Date: 2018-04
• Subjects: Thrombosis -- Periodicals; 616.135
• DOI: 10.1016/j.thromres.2018.02.146
• Languages: English
• ISSNs: 0049-3848

Abstract

Abstract: Introduction: Immune thrombocytopenia (ITP) is an immune-mediated disease; it has been reported to be associated with several diseases. The data on ITP in patients with hepatitis B, tuberculosis, or thyroid diseases are relatively scarce. In addition, these diseases are not rare in Taiwan, together with hepatitis C and Helicobacter pylori which are also related to ITP. Methods and materials: We identified 1223 ITP patients and characterized these patients between 2000 and 2013 from the National Health Insurance Research Database. The adult ITP patients were matched with non-ITP patients. Results: The overall incidence of ITP was 2.59/100, 000 person-years. The frequencies of hepatitis B and C in adult ITP patients were much higher than those indicated in previous studies. The frequencies of non-traumatic intracerebral hemorrhage and gastrointestinal bleeding during hospitalization among ITP patients were low. The diseases associated with increased risks of ITP included hepatitis B (OR = 18.70, 95% CI = 9.71–36.03), hepatitis C (OR = 54.43, 95% CI = 15.94–185.88), hepatitis B and hepatitis C (OR = 7.02, 95% CI = 1.47–33.56), tuberculosis (OR = 5.37, 95% CI = 2.72–10.61), Helicobacter pylori infection (OR = 5.93, 95% CI = 3.16–11.10), hyperthyroidism (OR = 3.43, 95% CI = 2.09–5.64), hypothyroidism (OR = 6.70, 95% CI = 2.35–19.13), and simple and unspecified goiter (OR = 2.68, 95% CI = 1.43–5.03). Conclusions: Surveying for the diseases which are frequent and related to increased risks of ITP among patients with newly diagnosed ITP should be considered. Highlights: The overall incidence of immune thrombocytopenia was 2.59/100, 000 person-years. Hepatitis B and C only in immune thrombocytopenia patients were higher in Taiwan. Hyperthyroidism and hypothyroidism increased risks of immune thrombocytopenia. Serious bleeding among immune thrombocytopenia patients was low.