Antibiotics and antibiotic resistance genes in global lakes: A review and meta-analysis. (July 2018)

• Record Type: Journal Article
• Authors: Yang, Yuyi; Song, Wenjuan; Lin, Hui; Wang, Weibo; Du, Linna; Xing, Wei
• Is Part Of: Environment international. Volume 116(2018)
• Page Start: 60
• Page End: 73
• Publication Date: 2018-07
• Subjects: Species sensitivity distributions -- Niche -- Aquatic biota -- Antibiotics -- Antibiotic resistance genes -- Meta-analysis; Environmental protection -- Periodicals; Environmental health -- Periodicals; Environmental monitoring -- Periodicals; Environmental Monitoring -- Periodicals; Environnement -- Protection -- Périodiques; Hygiène du milieu -- Périodiques; Environnement -- Surveillance -- Périodiques; Environmental health; Environmental monitoring; Environmental protection; Periodicals; 333.705
• DOI: 10.1016/j.envint.2018.04.011
• Languages: English
• ISSNs: 0160-4120

Abstract

Abstract: Lakes are an important source of freshwater, containing nearly 90% of the liquid surface fresh water worldwide. Long retention times in lakes mean pollutants from discharges slowly circulate around the lakes and may lead to high ecological risk for ecosystem and human health. In recent decades, antibiotics and antibiotic resistance genes (ARGs) have been regarded as emerging pollutants. The occurrence and distribution of antibiotics and ARGs in global freshwater lakes are summarized to show the pollution level of antibiotics and ARGs and to identify some of the potential risks to ecosystem and human health. Fifty-seven antibiotics were reported at least once in the studied lakes. Our meta-analysis shows that sulfamethoxazole, sulfamerazine, sulfameter, tetracycline, oxytetracycline, erythromycin, and roxithromycin were found at high concentrations in both lake water and lake sediment. There is no significant difference in the concentration of sulfonamides in lake water from China and that from other countries worldwide; however, there was a significant difference in quinolones. Erythromycin had the lowest predicted hazardous concentration for 5% of the species (HC5 ) and the highest ecological risk in lakes. There was no significant difference in the concentration of sulfonamide resistance genes ( sul1 and sul2 ) in lake water and river water. There is surprisingly limited research on the role of aquatic biota in propagation of ARGs in freshwater lakes. As an environment that is susceptible to cumulative build-up of pollutants, lakes provide an important environment to study the fate of antibiotics and transport of ARGs with a broad range of niches including bacterial community, aquatic plants and animals. Graphical abstract: Highlights: First comprehensive review of antibiotics and ARGs in lakes is shown. Species sensitivity distribution was used to analyse the risk of antibiotics. Quinolones in water of lakes from China are higher than other lakes worldwide. There is limited research on the role of aquatic biota on the propagation of ARGs. Lakes are an important environment to investigate the spread and transport of ARGs.