The effect of LILRB1 but not LILRA3 gene polymorphism in immunopathology of ankylosing spondylitis—A parallel to KIR genes. (20th March 2019)

• Record Type: Journal Article
• Authors: Majorczyk, Edyta; Wiśniewski, Andrzej; Zoń‐Giebel, Aleksandra; Chlebicki, Arkadiusz; Wiland, Piotr; Kuśnierczyk, Piotr
• Is Part Of: International journal of immunogenetics. Volume 46:Number 3(2019:Jun.)
• Page Start: 146
• Page End: 151
• Publication Date: 2019-03-20
• Subjects: ankylosing spondylitis -- genetics -- HLA‐B27 -- KIR -- LILR; Immunogenetics -- Periodicals; 571.9648
• DOI: 10.1111/iji.12422
• Languages: English
• ISSNs: 1744-3121

Abstract

Abstract: LILR and KIR receptors recognize HLA‐B27 and may influence immune response in ankylosing spondylitis (AS) development. Purpose of the study was to analyse LILRB1 / LILRA3 polymorphisms in AS. We observed a possible protective effect of the T allele of LILRB1 rs1061680:T>C and no association with insertion/deletion polymorphisms of LILRA3 with AS.