Immune cell trafficking, lymphatics and hypertension. (25th June 2018)

• Record Type: Journal Article
• Authors: Balasubbramanian, Dakshnapriya; Lopez Gelston, Catalina A; Rutkowski, Joseph M; Mitchell, Brett M
• Is Part Of: British journal of pharmacology. Volume 176:Number 12(2019)
• Page Start: 1978
• Page End: 1988
• Publication Date: 2018-06-25
• Subjects: Pharmacology -- Periodicals; Chemotherapy -- Periodicals; Drug Therapy -- Periodicals; Pharmacology -- Periodicals; 615.1
• DOI: 10.1111/bph.14370
• Languages: English
• ISSNs: 0007-1188

Abstract

Abstract : Activated immune cell infiltration into organs contributes to the development and maintenance of hypertension. Studies targeting specific immune cell populations or reducing their inflammatory signalling have demonstrated a reduction in BP. Lymphatic vessels play a key role in immune cell trafficking and in resolving inflammation, but little is known about their role in hypertension. Studies from our laboratory and others suggest that inflammation‐associated or induction of lymphangiogenesis is organ protective and anti‐hypertensive. This review provides the basis for hypertension as a disease of chronic inflammation in various tissues and highlights how renal lymphangiogenesis is a novel regulator of kidney health and BP. Linked Articles: This article is part of a themed section on Immune Targets in Hypertension. To view the other articles in this section visithttp://onlinelibrary.wiley.com/doi/10.1111/bph.v176.12/issuetoc