Current Advances in Immunomodulatory Biomaterials for Bone Regeneration. Issue 4 (17th October 2018)

• Record Type: Journal Article
• Authors: Lee, Jinkyu; Byun, Hayeon; Madhurakkat Perikamana, Sajeesh Kumar; Lee, Sangmin; Shin, Heungsoo
• Is Part Of: Advanced healthcare materials. Volume 8:Issue 4(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-10-17
• Subjects: biomaterial interfaces -- bone regeneration -- macrophages -- osteoimmunology; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.201801106
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract: Biomaterials with suitable surface modification strategies are contributing significantly to the rapid development of the field of bone tissue engineering. Despite these encouraging results, utilization of biomaterials is poorly translated to human clinical trials potentially due to lack of knowledge about the interaction between biomaterials and the body defense mechanism, the "immune system". The highly complex immune system involves the coordinated action of many immune cells that can produce various inflammatory and anti‐inflammatory cytokines. Besides, bone fracture healing initiates with acute inflammation and may later transform to a regenerative or degenerative phase mainly due to the cross‐talk between immune cells and other cells in the bone regeneration process. Among various immune cells, macrophages possess a significant role in the immune defense, where their polarization state plays a key role in the wound healing process. Growing evidence shows that the macrophage polarization state is highly sensitive to the biomaterial's physiochemical properties, and advances in biomaterial research now allow well controlled surface properties. This review provides an overview of biomaterial‐mediated modulation of the immune response for regulating key bone regeneration events, such as osteogenesis, osteoclastogenesis, and inflammation, and it discusses how these strategies can be utilized for future bone tissue engineering applications. Abstract : Recent approaches to biomaterial‐mediated immunomodulation for bone regeneration are summarized in this review. Engineered biomaterials with suitable properties can orchestrate the action of immune cells and their cross‐talk with key events in bone fracture healing such as osteogenesis, osteoclastogenesis, and inflammation. Such approaches can be a future tool for bridging the gap between laboratories to clinical trials for biomaterials.