Ultrathin Molybdenum Carbide MXene with Fast Biodegradability for Highly Efficient Theory‐Oriented Photonic Tumor Hyperthermia. (1st April 2019)

• Record Type: Journal Article
• Authors: Feng, Wei; Wang, Rongyan; Zhou, Yadan; Ding, Li; Gao, Xiang; Zhou, Bangguo; Hu, Ping; Chen, Yu
• Is Part Of: Advanced functional materials. Volume 29:Number 22(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-04-01
• Subjects: biodegradability -- cancer therapy -- Mo2C MXene -- nanomedicine -- photothermal conversion; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adfm.201901942
• Languages: English
• ISSNs: 1616-301X

Abstract

Abstract: The explosion of emerging high‐performance 2D MXenes in theranostic nanomedicine is still at the preliminary stage. Despite tremendous efforts devoted to photonic tumor hyperthermia, current photothermal‐conversion nanoagents still suffer from critical issues preventing further clinical translation such as low biodegradability. Here, for the first time, the construction of novel 2D molybdenum carbide (Mo2 C) MXenes for photonic tumor hyperthermia is reported. The structure of both bulk Mo2 Ga2 C ceramic and Mo2 C MXene is fully revealed. Especially, computational simulation, as a novel strategy and a powerful tool for photonic‐performance prediction, is employed to reveal that Mo2 C MXene is featured with intense near‐infrared (NIR) absorption, covering the first and the second biological transparency window (NIR I and II). After further surface engineering with polyvinyl alcohol (PVA), Mo2 C‐PVA nanoflakes exhibit high biocompatibility and fast degradability. Importantly, it is experimentally corroborated that Mo2 C‐PVA nanoflakes possess intriguing broad absorption band spanning NIR in both the I and II regions, and desirable photothermal‐conversion efficiency (24.5% for NIR I and 43.3% for NIR II). This study not only broadens the nanomedical applications of MXene by fabricating novel material members (Mo2 C), but also provides the paradigm of inorganic multifunctional biomedical nanoplatform with desirable biodegradability and high therapeutic performance. Abstract : Ultrathin molybdenum carbide (Mo2 C) nanoflakes (MXenes) are developed for photonic tumor hyperthermia, which possesses desirable biodegradability and high therapeutic performance. Computational simulation and experimental characterization are carried out to corroborate Mo2 C MXene with broad absorption band, spanning both the first and second near‐infrared biological regions.