Albizia julibrissin Ameliorates Memory Loss Induced by Insomnia in Drosophila. (1st April 2019)

• Record Type: Journal Article
• Authors: Chang, Jui-Shu; Liu, Hsin-Ping; Cheng, Jack; Chen, Chao-Jung; Hwang, Su-Lun; Tseng, Chi-Chuan; Hsu, Lee-Fen; Lin, Wei-Yong
• Other Names: Kuete Victor Academic Editor.
• Is Part Of: Evidence-based complementary and alternative medicine. Volume 2019(2019)
• Publication Date: 2019-04-01
• Subjects: Alternative medicine -- Periodicals; 615.505
• DOI: 10.1155/2019/7395962
• Languages: English
• ISSNs: 1741-427X

Abstract

Abstract : In clinical practice in Taiwan, Albizia julibrissin is the most prescribed Chinese herbal medicine for insomnia. Short-term insomnia and hypnotic use both attenuate cognitive functions, especially learning memory. In previous studies, A. julibrissin exhibits sedative activity, antidepressant-like effects, and protection of learning and memory against amnesia. However, whether A. julibrissin ameliorates memory loss caused by short-term sleep deprivation is not clear. We utilized the sleep-deprived Drosophila model and olfactory associative learning-memory assay to test the effects of A. julibrissin on sleep-deprivation induced memory loss. We found that A. julibrissin ameliorated 3-hour memory but not 1-hour memory or instant learning. The findings might be applied to an anticipated short-term sleep disturbance.