Patterns of care and survival outcomes for laryngeal small cell cancer. Issue 3 (10th December 2018)

• Record Type: Journal Article
• Authors: Lin, Alexander J.; Gabani, Prashant; Fischer‐Valuck, Ben; Rudra, Soumon; Gay, Hiram; Daly, Mackenzie; Oppelt, Peter; Jackson, Ryan; Rich, Jason; Paniello, Randal; Zevallos, Jose; Adkins, Douglas; Thorstad, Wade
• Is Part Of: Head & neck. Volume 41:Issue 3(2019)
• Page Start: 722
• Page End: 729
• Publication Date: 2018-12-10
• Subjects: chemotherapy -- head and neck -- neuroendocrine cancer -- radiation -- surgery; Head -- Diseases -- Periodicals; Neck -- Diseases -- Periodicals; Head -- Periodicals; Neck -- Periodicals; Face -- Periodicals; 617.51059
• DOI: 10.1002/hed.25430
• Languages: English
• ISSNs: 1043-3074

Abstract

Abstract: Background: To determine practice patterns and outcomes of laryngeal small cell cancer (LSCC) across the United States. Methods: Patients with LSCC were identified in the National Cancer Database. Overall survival (OS) was compared with Kaplan‐Meier analysis and Cox regression. Results: From 2004 to 2014, the 5‐year OS for early stage (n = 47), locally advanced stage (n = 133), and metastatic disease (n = 53) was 34%, 26%, and 9%, respectively. Chemoradiation was given in 66% of cases. Chemotherapy was less likely given in early stage disease ( P = .001), and definitive radiation was less likely given in metastatic disease ( P < .001). Definitive radiation improved median OS in locally advanced LSCC (20 vs. 7 months, log‐rank P = .04). In multivariable modeling, radiation dose ≥40 Gy was associated with better OS ( P < .001). Conclusion: Chemoradiation was the most common practice for treating locally advanced LSCC, and radiation dose ≥40 Gy was associated with improved OS.