Association of Maternal Obesity in Early Pregnancy with Adverse Pregnancy Outcomes: A Chinese Prospective Cohort Analysis. Issue 6 (8th May 2019)

• Record Type: Journal Article
• Authors: Zhou, Yubo; Li, Hongtian; Zhang, Yali; Zhang, Le; Liu, Jufen; Liu, Jianmeng
• Is Part Of: Obesity. Volume 27:Issue 6(2019)
• Page Start: 1030
• Page End: 1036
• Publication Date: 2019-05-08
• Subjects: Obesity -- Periodicals; 616.398005
• DOI: 10.1002/oby.22478
• Languages: English
• ISSNs: 1930-7381

Abstract

Abstract : Objective: This study aimed to examine the associations of maternal obesity in early pregnancy with adverse pregnancy outcomes. Methods: A prospective cohort analysis was performed among 18, 481 Chinese nulliparous women, using data from a 2006 to 2009 trial of prenatal micronutrient supplementation. Obesity was defined as BMI ≥ 27.5 kg/m 2 . Interested outcomes included fetal loss (spontaneous abortion plus stillbirth), infant death, total mortality, and preterm and birth weight outcomes. Results: Compared with normal weight, obesity was associated with total mortality (adjusted relative risks [ARR] 1.34; 95% CI: 1.03‐1.74) and fetal loss (ARR 1.51; 95% CI: 1.15‐1.99) but not with infant death (ARR 0.53; 95% CI: 0.20‐1.46). Further analyses showed that obesity was particularly associated with spontaneous abortion (ARR 1.51; 95% CI: 1.13‐2.02) rather than stillbirth (ARR 1.52; 95% CI: 0.65‐3.57). Moreover, obesity was associated with preterm birth (ARR 1.59; 95% CI: 1.25‐2.02), macrosomia (ARR 3.71, 95% CI: 3.01‐4.59), and large for gestational age (ARR 2.93; 95% CI: 2.49‐3.47). Conclusions: Maternal obesity in early pregnancy is associated with various adverse pregnancy outcomes in Chinese nulliparous women, suggesting the importance of an appropriate weight before and during pregnancy.