Sirtuins and Cancer: Role in the Epithelial-Mesenchymal Transition. (9th June 2016)

• Record Type: Journal Article
• Authors: Palmirotta, Raffaele; Cives, Mauro; Della-Morte, David; Capuani, Barbara; Lauro, Davide; Guadagni, Fiorella; Silvestris, Franco
• Other Names: Gomes Pedro Academic Editor.
• Is Part Of: Oxidative medicine and cellular longevity. Volume 2016(2016)
• Publication Date: 2016-06-09
• Subjects: Oxidative stress -- Periodicals; Cells -- Aging -- Periodicals; Cells -- Aging; Oxidative stress; Oxidative Stress -- Periodicals; Cell Aging -- Periodicals; Periodicals; 611.0181
• DOI: 10.1155/2016/3031459
• Languages: English
• ISSNs: 1942-0900

Abstract

Abstract : The human sirtuins (SIRT1–SIRT7) enzymes are a highly conserved family of NAD + -dependent histone deacetylases, which play a critical role in the regulation of a large number of metabolic pathways involved in stress response and aging. Cancer is an age-associated disease, and sirtuins may have a considerable impact on a plethora of processes that regulate tumorigenesis. In particular, growing evidence suggests that sirtuins may modulate epithelial plasticity by inducing transcriptional reprogramming leading to epithelial-mesenchymal transition (EMT), invasion, and metastases. Though commonly regarded as EMT inducers, sirtuins may also suppress this process, and their functional properties seem to largely depend on the cellular context, stage of cancer development, tissue of origin, and microenvironment architecture. Here, we review the role of sirtuins in cancer biology with particular emphasis on their role in EMT.