Cardiac H2S Generation Is Reduced in Ageing Diabetic Mice. (11th May 2015)

• Record Type: Journal Article
• Authors: Jin, Sheng; Pu, Shi-Xin; Hou, Cui-Lan; Ma, Fen-Fen; Li, Na; Li, Xing-Hui; Tan, Bo; Tao, Bei-Bei; Wang, Ming-Jie; Zhu, Yi-Chun
• Other Names: Yang Guangdong Academic Editor.
• Is Part Of: Oxidative medicine and cellular longevity. Volume 2015(2015)
• Publication Date: 2015-05-11
• Subjects: Oxidative stress -- Periodicals; Cells -- Aging -- Periodicals; Cells -- Aging; Oxidative stress; Oxidative Stress -- Periodicals; Cell Aging -- Periodicals; Periodicals; 611.0181
• DOI: 10.1155/2015/758358
• Languages: English
• ISSNs: 1942-0900

Abstract

Abstract : Aims . To examine whether hydrogen sulfide (H2 S) generation changed in ageing diabetic mouse hearts. Results . Compared to mice that were fed tap water only, mice that were fed 30% fructose solution for 15 months exhibited typical characteristics of a severe diabetic phenotype with cardiac hypertrophy, fibrosis, and dysfunction. H2 S levels in plasma, heart tissues, and urine were significantly reduced in these mice as compared to those in controls. The expression of the H2 S-generating enzymes, cystathionine γ -lyase and 3-mercaptopyruvate sulfurtransferase, was significantly decreased in the hearts of fructose-fed mice, whereas cystathionine- β -synthase levels were significantly increased. Conclusion . Our results suggest that this ageing diabetic mouse model developed diabetic cardiomyopathy and that H2 S levels were reduced in the diabetic heart due to alterations in three H2 S-producing enzymes, which may be involved in the pathogenesis of diabetic cardiomyopathy.