Antimicrobial studies, synthesis and characterization of novel 1-nitro-10H-phenothiazine bearing sulfone/nucleoside moieties. (3rd August 2019)

• Record Type: Journal Article
• Authors: Jangid, Dinesh Kumar; Guleria, Anjali; Gautam, Dinesh C.; Yadav, Hemendra; Mathur, Manas; Swami, Ajit Kumar
• Is Part Of: Nucleosides, nucleotides & nucleic acids. Volume 38:Number 8(2019)
• Page Start: 533
• Page End: 549
• Publication Date: 2019-08-03
• Subjects: One pot synthesis -- Smiles rearrangement -- phenothiazines -- sulfones -- ribofuranosides -- antimicrobial assessment; Nucleosides -- Periodicals; Nucleotides -- Periodicals; Nucleic acids -- Periodicals; 572.8
• DOI: 10.1080/15257770.2019.1576879
• Languages: English
• ISSNs: 1525-7770

Abstract

Abstract: The current research article involves one pot synthesis of novel substituted 1-nitro-10 H- phenothiazines via Smiles rearrangement. These substituted phenothiazines undergo oxidation to yield 10 H -phenothiazine-5, 5-dioxides (sulfones) while on treatment with β-D-ribofuranose-1-acetate-2, 3, 5-tribenzoate yield ribofuranosides. These compounds were screened for their antimicrobial vitalities ( in vitro ) against selected strains of bacteria and fungi. The characterization of synthesized compounds was done by elemental and spectral studies. GRAPHICAL ABSTRACT: