Epicatechin Reduces Striatal MPP+-Induced Damage in Rats through Slight Increases in SOD-Cu, Zn Activity. (2nd August 2015)

• Record Type: Journal Article
• Authors: Rubio-Osornio, M.; Gorostieta-Salas, E.; Montes, S.; Pérez-Severiano, F.; Rubio, C.; Gómez, C.; Ríos, C.; Guevara, J.
• Other Names: Korrapati Sathyasaikumar V. Academic Editor.
• Is Part Of: Oxidative medicine and cellular longevity. Volume 2015(2015)
• Publication Date: 2015-08-02
• Subjects: Oxidative stress -- Periodicals; Cells -- Aging -- Periodicals; Cells -- Aging; Oxidative stress; Oxidative Stress -- Periodicals; Cell Aging -- Periodicals; Periodicals; 611.0181
• DOI: 10.1155/2015/276039
• Languages: English
• ISSNs: 1942-0900

Abstract

Abstract : Parkinson's disease is a neurodegenerative disorder characterized by movement alterations caused by reduced dopaminergic neurotransmission in the nigrostriatal pathway, presumably by oxidative stress (OS). MPP + intrastriatal injection leads to the overproduction of free radicals (FR). The increasing formation of FR produces OS, a decline in dopamine (DA) content, and behavioral disorders. Epicatechin (EC) has shown the ability to be FR scavenger, an antioxidant enzyme inductor, a redox state modulator, and transition metal chelator. Acute administration of 100 mg/kg of EC significantly prevented (P < 0.05 ) the circling MPP + -induced behavior (10 μ g/8 μ L). Likewise, EC significantly (P < 0.05 ) reduced the formation of fluorescent lipid products caused by MPP + . MPP + injection produced (P < 0.05 ) increased enzymatic activity of the constitutive nitric oxide synthase (cNOS). This effect was blocked with acute EC pretreatment. Cu/Zn-dependent superoxide dismutase (Cu/Zn-SOD) activity was significantly (P < 0.05 ) reduced as a consequence of MPP + damage. EC produced a slight increase (≈20%) in Cu/Zn-SOD activity in the control group. Such effects persisted in animals injured with MPP + . The results show that EC is effective against MPP + -induced biochemical and behavioral damage, which is possible by an increase in Cu/Zn-SOD activity.