Hydrogen Sulfide Protects against Chronic Unpredictable Mild Stress-Induced Oxidative Stress in Hippocampus by Upregulation of BDNF-TrkB Pathway. (25th July 2016)

• Record Type: Journal Article
• Authors: Hu, Min; Zou, Wei; Wang, Chun-Yan; Chen, Xi; Tan, Hui-Ying; Zeng, Hai-Ying; Zhang, Ping; Gu, Hong-Feng; Tang, Xiao-Qing
• Other Names: Collino Massimo Academic Editor.
• Is Part Of: Oxidative medicine and cellular longevity. Volume 2016(2016)
• Publication Date: 2016-07-25
• Subjects: Oxidative stress -- Periodicals; Cells -- Aging -- Periodicals; Cells -- Aging; Oxidative stress; Oxidative Stress -- Periodicals; Cell Aging -- Periodicals; Periodicals; 611.0181
• DOI: 10.1155/2016/2153745
• Languages: English
• ISSNs: 1942-0900

Abstract

Abstract : Chronic unpredictable mild stress (CUMS) induces hippocampal oxidative stress. H2 S functions as a neuroprotectant against oxidative stress in brain. We have previously shown the upregulatory effect of H2 S on BDNF protein expression in the hippocampus of rats. Therefore, we hypothesized that H2 S prevents CUMS-generated oxidative stress by upregulation of BDNF-TrkB pathway. We showed that NaHS (0.03 or 0.1 mmol/kg/day) ameliorates the level of hippocampal oxidative stress, including reduced levels of malondialdehyde (MDA) and 4-hydroxy-2-trans-nonenal (4-HNE), as well as increased level of glutathione (GSH) and activity of superoxide dismutase (SOD) in the hippocampus of CUMS-treated rats. We also found that H2 S upregulated the level of BDNF and p-TrkB protein in the hippocampus of CUMS rats. Furthermore, inhibition of BDNF signaling by K252a, an inhibitor of the BDNF receptor TrkB, blocked the antioxidant effects of H2 S on CUMS-induced hippocampal oxidative stress. These results reveal the inhibitory role of H2 S in CUMS-induced hippocampal oxidative stress, which is through upregulation of BDNF/TrkB pathway.