Hydrogen Sulfide Improves Vascular Calcification in Rats by Inhibiting Endoplasmic Reticulum Stress. (28th February 2016)

• Record Type: Journal Article
• Authors: Yang, Rui; Teng, Xu; Li, Hui; Xue, Hong-Mei; Guo, Qi; Xiao, Lin; Wu, Yu-Ming
• Other Names: Olson Kenneth R. Academic Editor.
• Is Part Of: Oxidative medicine and cellular longevity. Volume 2016(2016)
• Publication Date: 2016-02-28
• Subjects: Oxidative stress -- Periodicals; Cells -- Aging -- Periodicals; Cells -- Aging; Oxidative stress; Oxidative Stress -- Periodicals; Cell Aging -- Periodicals; Periodicals; 611.0181
• DOI: 10.1155/2016/9095242
• Languages: English
• ISSNs: 1942-0900

Abstract

Abstract : In this study, the vitamin D3 plus nicotine (VDN) model of rats was used to prove that H2 S alleviates vascular calcification (VC) and phenotype transformation of vascular smooth muscle cells (VSMC). Besides, H2 S can also inhibit endoplasmic reticulum stress (ERS) of calcified aortic tissues. The effect of H2 S on alleviating VC and phenotype transformation of VSMC can be blocked by TM, while PBA also alleviated VC and phenotype transformation of VSMC that was similar to the effect of H2 S. These results suggest that H2 S may alleviate rat aorta VC by inhibiting ERS, providing new target and perspective for prevention and treatment of VC.