Bile Nephropathy in Flucloxacillin-Induced Cholestatic Liver Dysfunction. (24th February 2016)

• Record Type: Journal Article
• Authors: Alnasrallah, Basil; Collins, John F.; Zwi, L. Jonathan
• Other Names: Sayer John A. Academic Editor.
• Is Part Of: Case reports in nephrology. Volume 2016(2016)
• Publication Date: 2016-02-24
• Subjects: Nephrology -- Periodicals; Kidneys -- Diseases -- Periodicals; Nephrology; Kidneys -- Diseases; Nephrology; Periodicals; Electronic journals; Periodicals; 616.61
• DOI: 10.1155/2016/4162674
• Languages: English
• ISSNs: 2090-6641

Abstract

Abstract : Kidney injury in the context of cholestatic liver dysfunction is not uncommon; this has been historically referred to as cholemic nephrosis implying a direct deleterious renal effect of cholemia. However, scepticism about the exact role that bile and its constituents play in this injury has led to the disappearance of the term. We describe a case of severe AKI due to bile nephropathy with bile casts in flucloxacillin-induced liver dysfunction. We also discuss the recent literature reviving the concept of bile nephropathy.