Quartz crystal microbalance for telomerase sensing based on gold nanoparticle induced signal amplification. Issue 43 (3rd May 2019)

• Record Type: Journal Article
• Authors: Yang, Haitang; Li, Ying; Wang, Dingzhong; Liu, Yong; Wei, Wei; Zhang, Yuanjian; Liu, Songqin; Li, Peng
• Is Part Of: Chemical communications. Volume 55:Issue 43(2019)
• Page Start: 5994
• Page End: 5997
• Publication Date: 2019-05-03
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c9cc02610j
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A mass-sensitive quartz crystal microbalance biosensor was constructed for telomerase sensing based on gold nanoparticle induced signal amplification. Abstract : A novel circulating-flow quartz crystal microbalance (QCM) biosensing method has been established to detect telomerase. Oligonucleotide-functionalized gold nanoparticles (GNPs-cDNA) have been used to amplify the frequency change, which enable this QCM to be a sensitive biosensor for telomerase activity detection. The detection limit was as low as 37 cells per mL. The assay platform exhibited excellent selectivity.