Fatal Septic Shock in a Patient with Hemophagocytic Lymphohistiocytosis Associated with an Infectious Mononucleosis. (25th September 2018)

• Record Type: Journal Article
• Authors: Berlot, Giorgio; Tomasini, Ariella; Zandonà, Lorenzo; Leonardo, Eugenio; Bussani, Rossana; Zarrillo, Nadia
• Other Names: Molnár Zsolt Academic Editor.
• Is Part Of: Case reports in critical care. Volume 2018(2018)
• Publication Date: 2018-09-25
• Subjects: Critical care medicine -- Periodicals; Emergency medicine -- Periodicals; Medical emergencies -- Periodicals; 616.02805
• DOI: 10.1155/2018/9756050
• Languages: English
• ISSNs: 2090-6420

Abstract

Abstract : The authors describe the case of a young woman who developed a clinical pictures resembling a septic shock-related multiple organ dysfunction syndrome a couple of months after having been diagnosed suffering from a hemophagocytic lymphohistiocytosis associated with an infectious mononucleosis. Despite the aggressive treatment, which included antibiotics, vasopressors, IV immunoglobulins, and the use of an extracorporeal device aimed to remove mediators released both during sepsis and the cytokine storm determined by the hemophagocytic lymphohistiocytosis, the patient died. At the autopsy, an extremely uncommon aggressive lymphoma of Epstein-Barr virus-positive T-lymphocytes with systemic involvement was discovered.