Fluorination-triggered tandem cyclization of styrene-type carboxylic acids to access 3-aryl isocoumarin derivatives under microwave irradiation. Issue 20 (2nd May 2019)

• Record Type: Journal Article
• Authors: Yuan, Jinwei; Zeng, Fanlin; Mai, Wenpeng; Yang, Liangru; Xiao, Yongmei; Mao, Pu; Wei, Donghui
• Is Part Of: Organic & biomolecular chemistry. Volume 17:Issue 20(2019)
• Page Start: 5038
• Page End: 5046
• Publication Date: 2019-05-02
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c9ob00509a
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A practical synthetic route through a fluorination-triggered tandem cyclization of styrene-type carboxylic acids was developed to construct a variety of 4-fluoro-3-aryl-3, 4-dihydroisocoumarins and 3-arylisocoumarins. Abstract : A practical and straightforward synthetic route through a fluorination-triggered tandem cyclization of styrene-type carboxylic acids was developed to construct a variety of 4-fluoro-3-aryl-3, 4-dihydroisocoumarins and 3-arylisocoumarins under microwave irradiation. This novel protocol features mild reaction conditions and operational simplicity, with good yields.