The use of Free Style Libre Continues Glucose Monitoring (FSL-CGM) to monitor the impact of Ramadan fasting on glycemic changes and kidney function in high-risk patients with diabetes and chronic kidney disease stage 3 under optimal diabetes care. (May 2019)

• Record Type: Journal Article
• Authors: Alawadi, Fatheya; Rashid, Fauzia; Bashier, Alaaeldin; Abdelgadir, Elamin; Al Saeed, Maryam; Abuelkheir, Sona; Khalifa, Azza; Al sayyah, Fatima; Bachet, Fawzi; Elsayed, Mohammed; Abdallah, Khadija; Hassanein, Mohamed
• Is Part Of: Diabetes research and clinical practice. Volume 151(2019)
• Page Start: 305
• Page End: 312
• Publication Date: 2019-05
• Subjects: Diabetes -- Ramadan -- Fasting -- CKD -- Hypoglycemia -- CGMS; DM Diabetes Mellitus -- CKD-3 Chronic kidney Stage disease stage-3 -- T1DM Type 1 Diabetes -- T2DM Type 2 Diabetes -- HbA1c Glycated hemoglobin -- FSL-CGMS FreeStyle Libre flash-Continuous Glucose Monitoring System -- SMBG Self-Monitoring of Blood Glucose -- CSII Continuous Subcutaneous Insulin Infusion -- ADA American Diabetic Association -- IDF International Diabetes Federation -- DaR Diabetes and Ramadan international Alliance -- SU SulphonylUrea -- GLP-1 RA glucagon-like peptide-1 receptor agonist -- SGLT 2 I Sodium Glucose Co Transport Inhibitor -- DPP4I Dipeptidyl Transferase 4 Inhibitors -- UAE United Arab Emirates -- HDL High Density Lipoprotein -- LDL Low Density Lipoprotein -- BP Blood Pressure -- HE Hypoglycemic Events; Diabetes -- Periodicals; Diabetes Mellitus -- Periodicals; 616.462
• DOI: 10.1016/j.diabres.2019.03.015
• Languages: English
• ISSNs: 0168-8227

Abstract

Abstract: Aim: To understand the risk of hypoglycaemia during Ramadan fasting by use of CGM, as well as to observe the Glycemic control and renal functions in patients with diabetes and chronic kidney disease stage 3 (CKD-3). Method: A prospective interventional study conducted in the Dubai Hospital, a tertiary care centre in the United Arab Emirates, during the month of Ramadan 1437 AH (Hijri), which corresponded to June 6th till July 5th, 2016. 25 patients with type 2 diabetes and stage 3 chronic kidney disease (CKD stage 3) were included in the study, who intended to fast during Ramadan. The aim was to observe the serum glucose level through 24 h FreeStyle Libre flash continuous glucose monitor (FSL-CGM). Most patients had three sensors during the study, covering an average three weeks during Ramadan and three weeks outside Ramadan (Sha'ban and shawal). We also monitored the change in, BP, HBA1c, kidney functions and BMI before and after Ramadan. Results: This study included 25 adults with a mean age of 60 (±14 years). Fasting Ramadan did not result in any significant change in biophysical and biochemical profile of these patients. Data from FSL-CGM showed significantly longer duration (101.9 ± 119.1 Vs. 45.9 ± 47.6 min, p < 0.033) and more frequent hypoglycemic episodes (4.4 ± 4.7 Vs. 2.3 ± 3.0, p < 0.047) during Ramadan compared tonon-Ramadan respectively. The mean blood glucose readings were also significantly lower (70.7 ± 29.3 Vs.93.7 ± 57.9 mg/dl p < 0.011) during Ramadan compared to non -fasting period. The renal function mean ± SD (serum creatinine 1.48 ± 0.37, 1.44 ± 0.37 and eGFR, 49.0 ± 18.4, 48.9 ± 17.5 p 0.9) showed no significant change due to fasting. Conclusion: In patients with diabetes and CKD-stage 3 Ramadan fasting under close supervision and optimal diabetes care, was not associated with worsening of HBA1c and renal function. Patients had significantly more frequent and prolonged hypoglycemic episodes during Ramadan.