Effects of Short Term Exposure of Atrazine on the Liver and Kidney of Normal and Diabetic Rats. (29th September 2014)

• Record Type: Journal Article
• Authors: Jestadi, Dinesh Babu; Phaniendra, Alugoju; Babji, Undru; Srinu, Thupakula; Shanmuganathan, Bhavatharini; Periyasamy, Latha
• Other Names: O'Brien Peter J. Academic Editor.
• Is Part Of: Journal of toxicology. Volume 2014(2014)
• Publication Date: 2014-09-29
• Subjects: Toxicology -- Periodicals; 571.9505
• DOI: 10.1155/2014/536759
• Languages: English
• ISSNs: 1687-8191

Abstract

Abstract : The present study evaluates the effects of short term (15 days) exposure of low dose (300 μ g kg −1 ) of atrazine (2-chloro-4-ethylamino-6-isopropylamino-1, 3, 5-triazine) on antioxidant status and markers of liver and kidney damage in normal (nondiabetic) and diabetic male Wistar rats. Rats were divided into four groups: Group I as normal control, Group II as atrazine treated, Group III as diabetic control, and Group IV as atrazine treated diabetic rats. Atrazine administration resulted in increased MDA concentration as well as increased activities of SOD, CAT, and GPx in both liver and kidney of atrazine treated and atrazine treated diabetic rats. However, GSH level was decreased in both liver and kidney of atrazine treated and atrazine treated diabetic rats. Atrazine administration led to significant increase in liver damage biomarkers such as AST, ALT, and ALP as well as kidney damage biomarkers such as creatinine and urea in both normal and diabetic rats, but this increase was more pronounced in diabetic rats when compared to normal rats. In conclusion, the results of the present study demonstrate that short term exposure of atrazine at a dose of 300 μ g kg −1 could potentially induce oxidative damage in liver and kidney of both normal and diabetic rats.