Importance of tumor budding grade as independent prognostic factor for early tongue squamous cell carcinoma. Issue 6 (11th January 2019)

• Record Type: Journal Article
• Authors: Ebihara, Yasuhiro; Yoshida, Saori; Nakahira, Mitsuhiko; Kogashiwa, Yasunao; Enoki, Yuichiro; Kuba, Kiyomi; Inoue, Hitoshi; Minami, Kazuhiko; Yasuda, Masanori; Sugasawa, Masashi
• Is Part Of: Head & neck. Volume 41:Issue 6(2019)
• Page Start: 1809
• Page End: 1815
• Publication Date: 2019-01-11
• Subjects: budding -- early tongue cancer -- lymph node metastasis -- multivariate analysis -- prognostic factor; Head -- Diseases -- Periodicals; Neck -- Diseases -- Periodicals; Head -- Periodicals; Neck -- Periodicals; Face -- Periodicals; 617.51059
• DOI: 10.1002/hed.25614
• Languages: English
• ISSNs: 1043-3074

Abstract

Abstract: Background: Factors involved in neck lymph node metastasis (NLM) and prognosis of early tongue squamous cell carcinoma (SCC) remain unknown. Methods: We analyzed disease‐specific survival (DSS) and NLM including tumor budding grade (TBG) among 64 patients with cT1/2N0 tongue SCC. Results: Univariate analysis of DSS of primary lesions uncovered significant differences in new cT, pT, new pT, pDiameter, venous infiltration, and TBG. Multivariate analysis selected only TBG3 as a predictor of NLM (odds ratio, 9.55; 95% confidence interval [CI], 1.80‐50.8; P = .008), and a prognostic factor for DSS (hazard ratio, 4.41; 95% CI, 1.34‐14.5; P = .02). Conclusion: The sole predictor of NLM and the prognosis of early tongue SCC was TBG, indicating that it might help to select overwhelming risk patients.