Assessment of individual bioequivalence using sufficient bootstrap procedure. (20th January 2019)

• Record Type: Journal Article
• Authors: Beyaztas, Ufuk
• Is Part Of: Pharmaceutical statistics. Volume 18:Number 3(2019)
• Page Start: 388
• Page End: 398
• Publication Date: 2019-01-20
• Subjects: bioequivalence -- bootstrap -- hypothesis testing; Pharmacy -- Statistical methods -- Periodicals; Pharmacy -- Statistics -- Periodicals; 615.10727
• DOI: 10.1002/pst.1930
• Languages: English
• ISSNs: 1539-1604

Abstract

Abstract : This paper proposes a sufficient bootstrap method, which uses only the unique observations in the resamples, to assess the individual bioequivalence under 2 × 4 randomized crossover design. The finite sample performance of the proposed method is illustrated by extensive Monte Carlo simulations as well as a real‐experimental data set, and the results are compared with those obtained by the traditional bootstrap technique. Our records reveal that the proposed method is a good competitor or even better than the classical percentile bootstrap confidence limits.