Swelling degree prediction of polyhydroxybutyrate/chitosan matrices loaded with "Arnica‐do‐Brasil". Issue 32 (11th April 2019)

• Record Type: Journal Article
• Authors: Silva, Glauco Fonseca; da Silva, Talita Goulart; Gobbi, Vinícius Guedes; Portela, Theresa Lomeu; Teixeira, Bruna Nunes; dos Santos Mendonça, Tiago; da Silva Moreira Thiré, Rossana Mara; Oliveira, Renata Nunes; Yaunner, Ricardo Stutz; de Almeida Rodrigues Junior, Jorge; Mendonça, Roberta Helena
• Is Part Of: Journal of applied polymer science. Volume 136:Issue 32(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-04-11
• Subjects: biomaterial -- drug delivery -- interpolation -- spline; Polymers -- Periodicals; Polymerization -- Periodicals; 668.9
• DOI: 10.1002/app.47838
• Languages: English
• ISSNs: 0021-8995

Abstract

ABSTRACT: Polyhydroxybutyrate and chitosan have been studied as materials for drug delivery systems (DDSs) due to their biodegradability and biocompatibility. The aim of this work was to produce amphiphilic polyhydroxybutyrate/chitosan matrices that form porous structures (scaffolds) after swelling in water and arnica extract. The matrices were analyzed by TGA, SEM, XDR, DSC, and FTIR. Thin plate spline interpolation method (TPSIM) was used to predict the swelling of the matrices generating three‐dimensional data fitted, showing the influence of time and concentration variables on both fluids absorption. Polyhydroxybutyrate/chitosan samples containing 60 wt % (weight percent) of chitosan formed a porous structure as they were submitted to arnica loading, and the obtained device was able to deliver arnica in physiological medium. Thus, the produced matrices have a strong potential to perform both as scaffolds and DDS © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci.2019, 136, 47838. Abstract :