Frequency of Neurological Disorders in Bullous Pemphigoid Patients: A Cross-Sectional Study. (24th May 2017)

• Record Type: Journal Article
• Authors: Khosravani, Sheida; Handjani, Farhad; Alimohammadi, Reyhaneh; Saki, Nasrin
• Other Names: Alaibac Mauro Academic Editor.
• Is Part Of: International scholarly research notices. Volume 2017(2017)
• Publication Date: 2017-05-24
• Subjects: Medical sciences -- Periodicals; Life sciences -- Periodicals; Medicine -- Periodicals; Science -- Periodicals; Biomedical Technology; Biological Science Disciplines; Medicine; Life sciences; Medical sciences; Medicine; Science; Periodical; Periodicals; Fulltext; Internet Resources; Periodicals; Electronic journals
• DOI: 10.1155/2017/6053267
• Languages: English
• ISSNs: 2356-7872

Abstract

Abstract : Background . Bullous pemphigoid (BP) is an autoimmune subepidermal blistering skin disorder which occurs mostly in the elderly. Several studies have reported an association between BP and neurological disorders (ND). Objective . The purpose of this study was to evaluate the association between BP and neurological disorders in Iranian patients. Methods . In this cross-sectional study, 87 patients with BP were enrolled. They were compared to 184 controls. Statistical analysis was done by SPSS statistical software version 19. Results . Out of 87 patients with BP, 17 (19.5%) had at least one neurological disease. Cerebrovascular accident (CVA) was the most common neurological disease that was seen in 7 patients (8.0%) in the case group and 4 (2.1%) in the control group. The incidence of CVA was significantly different between BP patients and the control group (P = 0.022 ). Dementia was observed in 6 patients in the case group (16.8%) and 2 (1.0%) in the control group. The incidence of dementia was significantly different between BP patients and the control group (P = 0.008 ). In this study, the incidences of Parkinson's disease (P = 0.830 ), epilepsy (P = 0.067 ), and multiple sclerosis (P = 0.326 ) were not statistically significant between the two groups. Conclusion . The incidence of CVA and dementia in patients with BP compared to the control group was significantly higher.