Values of Alpha 1 Microglobulin Does Not Differ between Individuals with and without Family History of Balkan Endemic Nephropathy. (19th January 2014)

• Record Type: Journal Article
• Authors: Aleckovic-Halilovic, Mirna; Mesic, Enisa; Trnacevic, Senaid; Hodzic, Emir; Habul, Vildana; Atic, Mirza; Dugonjic, Maida; Hasanovic, Evlijana
• Other Names: Tesař Vladimír Academic Editor.
• Is Part Of: International journal of nephrology. Volume 2014(2014)
• Publication Date: 2014-01-19
• Subjects: Nephrology -- Periodicals; Nephrology; Kidney Diseases; Nephrology; Periodicals; Periodicals; Fulltext; Internet Resources; Electronic journals; 616.61
• DOI: 10.1155/2014/284293
• Languages: English
• ISSNs: 2090-214X

Abstract

Abstract : Aim . The aim of this study was to compare urinary alpha 1 microglobulin (A1MG) in healthy individuals with and without family burden for Balkan endemic nephropathy (BEN) in an endemic village. Methods . Otherwise healthy inhabitants with microalbuminuria or proteinuria were divided into two groups: with (n = 24 ) and without (n = 32 ) family BEN burden and screened for urinary A1MG and A1MG/urine creatinine ratio. Results . Average value of urinary A1MG was10.35 ± 7.01 mg/L in group with and10.79 ± 8.27 mg/L in group without family history for BEN (NS, P = 0.87 ). A1MG was higher than 10 mg/L in eight (33.33%) inhabitants with family history and in 12 (37.5%) without (NS, P = 0.187 ). Average values of urinary A1MG/creatinine ratio were1.30 ± 1.59 and0.94 ± 0.78 in group with and group without family BEN history (NS, P = 0.39, resp.). Elevated values of this ratio were found in 13 (54.17%) inhabitants with and 14 (43.75%) without family history for BEN (NS, P = 0.415 ). Conclusion . We did not find statistically significant difference in the examined markers between healthy individuals with and without family burden for BEN. We concluded that these markers are not predictive of risk for BEN.