Renal Damage Frequency in Patients with Solitary Kidney and Factors That Affect Progression. (10th December 2015)

• Record Type: Journal Article
• Authors: Basturk, T.; Koc, Y.; Ucar, Z.; Sakaci, T.; Ahbap, E.; Kara, E.; Bayraktar, F.; Sevinc, M.; Sahutoglu, T.; Kayalar, A.; Sinangil, A.; Akgol, C.; Unsal, A.
• Other Names: Amore Alessandro Academic Editor.
• Is Part Of: International journal of nephrology. Volume 2015(2015)
• Publication Date: 2015-12-10
• Subjects: Nephrology -- Periodicals; Nephrology; Kidney Diseases; Nephrology; Periodicals; Periodicals; Fulltext; Internet Resources; Electronic journals; 616.61
• DOI: 10.1155/2015/876907
• Languages: English
• ISSNs: 2090-214X

Abstract

Abstract : Background . The aim of this study is to assess renal damage incidence in patients with solitary kidney and to detect factors associated with progression. Methods . Medical records of 75 patients with solitary kidney were investigated retrospectively and divided into two groups: unilateral nephrectomy (group 1) and unilateral renal agenesis/dysplasia (group 2). According to the presence of kidney damage, each group was divided into two subgroups: group 1a/b and group 2a/b. Results . Patients in group 1 were older than those in group 2 (p = 0.001 ). 34 patients who comprise group 1a had smaller kidney size (p = 0.002 ) and higher uric acid levels (p = 0.028 ) than those in group 1b at presentation. Uric acid levels at first and last visit were associated with renal damage progression (p = 0.004, 0.019). 18 patients who comprise group 2a were compared with those in group 2b in terms of presence of DM (p = 0.038 ), HT (p = 0.003 ), baseline proteinuria (p = 0.014 ), and uric acid (p = 0.032 ) levels and group 2a showed higher rates for each. Progression was more common in patients with DM (p = 0.039 ), HT (p = 0.003 ), higher initial and final visit proteinuria (p = 0.014, for both), and higher baseline uric acid levels (p = 0.047 ). Conclusions . The majority of patients with solitary kidney showed renal damage at presentation. Increased uric acid level is a risk factor for renal damage and progression. For early diagnosis of renal damage and reducing the risk of progression, patients should be referred to a nephrologist as early as possible.