Synthesis and Evaluation of Enalapril‐Loaded PVA/PMC Modified Magnetic Nanoparticles as a Novel Efficient Nano‐Carrier. Issue 18 (13th May 2019)

• Record Type: Journal Article
• Authors: Shahverdi, Negin; Heydarinasab, Amir; Panahi, Homayon Ahmad; Moniri, Elham
• Is Part Of: ChemistrySelect. Volume 4:Issue 18(2019)
• Page Start: 5246
• Page End: 5250
• Publication Date: 2019-05-13
• Subjects: Magnetic properties -- Nanoparticles -- Adsorption -- Surface chemistry -- Drug Delivery; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.201900697
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: In the present study, the development of new Enalapril‐loaded adsorbent and evaluation of drug release was studied in vitro. Initially, Fe3 O4 magnetic nanoparticles were synthesized via co‐precipitation method. Then, the mixture of polymers was deposited on the surface of the magnetic nanoparticles via radical polymerization in order to enhance the adsorption capacity of nanoparticles with biocompatible poly methylcellulose modified with polyvinyl alcohol. The equilibrium adsorption data magnetite nano‐sorbent were analyzed using Langmuir, Freundlich, and Temkin. The drug‐release study showed that 80% of Enalapril released in the simulated gastrointestinal environment for 18 hours. The samples and products analyzed by FTIR, elemental analysis, thermal gravimetric analysis (TGA) and scanning electron microscopy (SEM). Adsorption parameters such as pH, temperature and contact time were optimized, and Langmuir, Freundlich and Temkin's isotherms were studied for the drug adsorption mechanism. The release process of Enalapril studied in the simulated human digestive environment. The release profile of Enalapril has a very steep slope for 30 minutes in the simulated human gastric. Abstract : The development of Enalapril‐loaded nano‐carrier and evaluation of drug release was studied in vitro in this study. Surface modification of nanomagnetic particles consists of deposition of biocompatible poly methylcellulose modified with polyvinyl alcohol via radical polymerization in order to enhance the adsorption capacity. Results showed 80% of Enalapril released in the simulated gastrointestinal environment for 18 hours from the nano‐carrier products.