Efficacy of an orally administered anti‐diarrheal probiotic paste (Pro‐Kolin Advanced) in dogs with acute diarrhea: A randomized, placebo‐controlled, double‐blinded clinical study. (18th March 2019)

• Record Type: Journal Article
• Authors: Nixon, Sophie L.; Rose, Lindsay; Muller, Annika T.
• Is Part Of: Journal of veterinary internal medicine. Volume 33:Number 3(2019)
• Page Start: 1286
• Page End: 1294
• Publication Date: 2019-03-18
• Subjects: Enterococcus faecium -- kaolin -- montmorillonite -- pectin -- prebiotic -- Pro‐Kolin Advanced; Veterinary medicine -- Periodicals; 636.0896
• DOI: 10.1111/jvim.15481
• Languages: English
• ISSNs: 0891-6640

Abstract

Abstract: Background: Acute diarrhea is a common clinical presentation of dogs. The effect of specific anti‐diarrheal probiotic pastes (ADPPs) in the management of acute, uncomplicated diarrhea in dogs is unknown. Hypothesis: Administration of an ADPP containing Enterococcus faecium 4b1707 will improve the clinical outcome of acute, uncomplicated diarrhea in dogs compared to placebo. Animals: One hundred forty‐eight client‐owned dogs with acute diarrhea as the main clinical sign. Methods: Double‐blinded, placebo‐controlled, randomized, blocked, multicenter clinical field study conducted at 14 primary care veterinary practices in the United Kingdom and Ireland. Results: The ADPP was associated with better clinical outcome compared to placebo in dogs with acute, uncomplicated diarrhea. Dogs in the ADPP group had a significantly shorter duration of diarrhea (ADPP: median, 32 hours; 95% confidence interval [CI], 2‐118; n = 51; Placebo: median, 47 hours; 95% CI, 4‐167; n = 58; P = .008) and the rate of resolution of diarrhea was 1.60 times faster in the ADPP group than in the Placebo group (ratio, 1.60; 95% CI, 1.08‐2.44; P = .02). Fewer dogs required additional medical intervention (AMI) for non‐improvement or worsening in the ADPP group compared to the Placebo group (3.5% of dogs and 14.8% of dogs, respectively), with a relative risk of 0.88 ( P = .04; AMI, ADPP, 3.5%, 2/57 dogs; Placebo, 14.8%, 9/61 dogs; relative risk, 0.88; 95% CI, 0.77‐0.99). Conclusion and Clinical Importance: The ADPP may accelerate resolution of acute diarrhea in dogs and decrease the requirement for AMI.