Full‐term newborn infant with blistering skin lesions—Caution regarding use of pain medications. Issue 3 (10th March 2019)

• Record Type: Journal Article
• Authors: Hussain, Aamir; Sanders, Melinda; Riotte, Clare; Hussain, Naveed
• Is Part Of: Pediatric dermatology. Volume 36:Issue 3(2019)
• Page Start: 362
• Page End: 364
• Publication Date: 2019-03-10
• Subjects: blistering skin lesions -- mast cell degranulation -- mastocytosis -- neonatology -- opioid use -- opioid use in neonates; Pediatric dermatology -- Periodicals; Children -- Diseases -- Periodicals; 618.925
• DOI: 10.1111/pde.13794
• Languages: English
• ISSNs: 0736-8046

Abstract

Abstract: Multiple opioids are known to trigger mast cell degranulation. We report the case of a neonate with blistering skin lesions at birth who died of multi‐organ failure after administration of morphine. Given the excessive histamine release and potential complications associated with morphine administration, alternative opioids and adjuvants should be considered in infants presenting with evidence of bullous or infiltrative skin lesions until mastocytosis is ruled out.