Kinetics Investigation on Mushroom Tyrosinase Inhibition of Proso Millet. (12th February 2018)

• Record Type: Journal Article
• Authors: Huang, Wen-Ying; Chen, Hui-Ju; Lin, Chia-Ching; Chen, Chin-Shuh; Lin, Yung-Sheng
• Other Names: Curcio Manuela Academic Editor.
• Is Part Of: Journal of chemistry. Volume 2018(2018)
• Publication Date: 2018-02-12
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1155/2018/2387926
• Languages: English
• ISSNs: 2090-9063

Abstract

Abstract : Proso millet (Panicum miliaceum) is rich in nutritive components and is widely used as a human food, feed and forage for animals, and fuel. This study investigated the effect of a proso millet extract on the inhibition of tyrosinase, a key enzyme in melanogenesis. High performance liquid chromatography analysis indicated that the proso millet extract contained phenolic tyrosinase inhibitors, such as syringic acid, p -coumaric acid, and ferulic acid. The extract had an IC50 for inhibition of tyrosinase activity of 14.02 mg/mL. A Lineweaver-Burk double reciprocal plot showed that the proso millet extract functioned as a mixed competitive and noncompetitive inhibitor. Proso millet has potential as a tyrosinase inhibitor that may have applications in the cosmetics industry.