Synthesis, Characterization, X-Ray Crystallography, and Antileishmanial Activities of N-Linked and O-Linked Glycopyranosides. (30th January 2018)

• Record Type: Journal Article
• Authors: Rashid, Haroon ur; Khan, Sher Wali; Khan, Momin; Nadhman, Akhtar; Rehman, Noor; Tariq, Muhammad; Yousuf, Sammer
• Other Names: Tiwari Vinod Kumar Academic Editor.
• Is Part Of: Journal of chemistry. Volume 2018(2018)
• Publication Date: 2018-01-30
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1155/2018/9648710
• Languages: English
• ISSNs: 2090-9063

Abstract

Abstract : NovelN -linked5a –e andO -linked glycopyranosides7a –e were synthesized in high yield from commercially available L-tartaric acid containing two asymmetric centers andC 2 axis of symmetry. The compound L-tartaric acid was completely protected and then partially hydrolyzed to get the monoester, which upon treatment with different amino and hydroxyl derivatives of glycopyranoses gave the desired amides and esters. The synthesized derivatives were purified by chromatography and characterized by spectroanalytical techniques. The structure of compound7c in the series was supported by X-ray analysis. Leishmanicidal activities of compounds5a –e and7a –e were investigated which showed moderate to good activities.