Back Cover: Identification and Quantification of Proteoforms by Mass Spectrometry. Issue 10 (15th May 2019)

• Record Type: Journal Article
• Authors: Schaffer, Leah V.; Millikin, Robert J.; Miller, Rachel M.; Anderson, Lissa C.; Fellers, Ryan T.; Ge, Ying; Kelleher, Neil L.; LeDuc, Richard D.; Liu, Xiaowen; Payne, Samuel H.; Sun, Liangliang; Thomas, Paul M.; Tucholski, Trisha; Wang, Zhe; Wu, Si; Wu, Zhijie; Yu, Dahang; Shortreed, Michael R.; Smith, Lloyd M.
• Is Part Of: Proteomics. Volume 19:Issue 10(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-05-15
• Subjects: Proteins -- Separation -- Periodicals; Bioinformatics -- Periodicals; Proteomics -- Periodicals; Genomes -- Periodicals; Molecular genetics -- Periodicals; 572.605
• DOI: 10.1002/pmic.201970085
• Languages: English
• ISSNs: 1615-9853

Abstract

Abstract : DOI:10.1002/pmic.201800361 A proteoform is a defined form of a protein derived from a given gene with a specific amino acid sequence and localized post‐translational modifications. In top‐down proteomic analyses, proteoforms are identified and quantified through mass spectrometric analysis of intact proteins. Recent technological developments have enabled comprehensive proteoform analyses in complex samples, and an increasing number of laboratories are adopting top‐down proteomic workflows. In article number1800361, Leah V. Schaffer et al. outline recent advances and discuss current challenges and future directions for the field.