Human leukocyte antigen associations in postural tachycardia syndrome. Issue 5 (4th April 2019)

• Record Type: Journal Article
• Authors: Shin, Yong‐Won; Moon, Jangsup; Kim, Tae‐Joon; Kim, Do‐Yong; Chang, Hyeyeon; Jun, Jin‐Sun; Lee, Soon‐Tae; Jung, Keun‐Hwa; Park, Kyung‐Il; Jung, Ki‐Young; Kim, Manho; Lee, Sang Kun; Chu, Kon
• Is Part Of: Annals of clinical and translational neurology. Volume 6:Issue 5(2019)
• Page Start: 962
• Page End: 967
• Publication Date: 2019-04-04
• Subjects: Nervous system -- Diseases -- Periodicals; Neurology -- Periodicals; 616.8005
• DOI: 10.1002/acn3.766
• Languages: English
• ISSNs: 2328-9503

Abstract

Abstract: Associations between human leukocyte antigen (HLA) and postural orthostatic tachycardia syndrome (POTS) have not been investigated. We included patients diagnosed with POTS and showing orthostatic heart rate increases ≥ 50 during orthostatic vital sign measurement or experiencing syncope/near‐syncope while standing (prominent POTS; n = 17). DQB1*06:09 was present in seven (41%) patients, a significantly higher percentage than in healthy Koreans (7%; odds ratio [OR] 8.7, 95% confidence interval [CI] 3.1–24.3, corrected P = 3.2 × 10 −4 ) and epilepsy controls (8%; OR 7.9, 95% CI 2.7–23.5, corrected P = 3.2 × 10 −4 ). Six (35.3%) carried the A*33:03‐B*58:01‐C*03:02‐DRB1*13:02‐DQB1*06:09 haplotype. The results signify an autoimmune etiology in prominent POTS.