Synthesis and Antibacterial Activity of New Spiro[thiadiazoline-(pyrazolo[3, 4-d]pyrimidine)] Derivatives. (13th May 2015)

• Record Type: Journal Article
• Authors: El Fal, Mohammed; Ramli, Youssef; Zerzouf, Abdelfettah; Talbaoui, Ahmed; Bakri, Youssef; Essassi, El Mokhtar
• Other Names: Radi Marco Academic Editor.
• Is Part Of: Journal of chemistry. Volume 2015(2015)
• Publication Date: 2015-05-13
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1155/2015/982404
• Languages: English
• ISSNs: 2090-9063

Abstract

Abstract : New heterocyclic compounds spiroderivatives of allopurinol of biological interest were prepared from allopurinol via thionation and 1, 3-dipolar cycloaddition and were produced in high to excellent yields. These compounds were characterized on the basis of spectral and spectroscopic data ( 1 H NMR, 13 C, IR, and MS). The antibacterial activity of the synthesized products was studied using bacterial strains: Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, and Pseudomonas aeruginosa . Compounds having an ethyl group showed the best activity with MIC value of 31.25 µ g/mL against Staphylococcus aureus and Streptococcus fasciens .