Synthesis and In Vitro Biological Evaluation of Aminonaphthoquinones and Benzo[b]phenazine-6, 11-dione Derivatives as Potential Antibacterial and Antifungal Compounds. (28th June 2015)

• Record Type: Journal Article
• Authors: Tuyun, Amaç Fatih; Bayrak, Nilüfer; Yıldırım, Hatice; Onul, Nihal; Mataraci Kara, Emel; Ozbek Celik, Berna
• Other Names: Radi Marco Academic Editor.
• Is Part Of: Journal of chemistry. Volume 2015(2015)
• Publication Date: 2015-06-28
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1155/2015/645902
• Languages: English
• ISSNs: 2090-9063

Abstract

Abstract : A series of 2-arylamino-3-chloro-1, 4-naphthoquinone derivatives (3a –h ) by the reaction of 2, 3-dichloro-1, 4-naphthoquinone with aryl amines (2a –h ) and benzo[ b ]phenazine-6, 11-dione derivatives (4a –c ) by the treatment of 2-arylamino-3-chloro-1, 4-naphthoquinone derivatives (3a –h ) with sodium azide were synthesized and tested for their in vitro antibacterial and antifungal activities. The results suggest that compounds3d and3g had potent antifungal activity against Candida albicans (MIC = 78.12 μ g/mL). All synthesized compounds (3a –h, 4a –c ) possessed activity against E. faecalis with MIC values of between 312.5 and 1250 μ g/mL. Benzo[ b ]phenazine-6, 11-dione derivatives (4a –c ) were mostly active against Gram-positive bacteria. The structures of the new members of the series were established on the basis of their spectral properties (IR, 1 H NMR, 13 C NMR, and mass spectrometry).