NIR‐Triggered Phototherapy and Immunotherapy via an Antigen‐Capturing Nanoplatform for Metastatic Cancer Treatment. Issue 10 (13th March 2019)

• Record Type: Journal Article
• Authors: Wang, Meng; Song, Jun; Zhou, Feifan; Hoover, Ashley R.; Murray, Cynthia; Zhou, Benqing; Wang, Lu; Qu, Junle; Chen, Wei R.
• Is Part Of: Advanced science. Volume 6:Issue 10(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-03-13
• Subjects: antigen capture -- immunotherapy -- metastatic cancer -- phototherapy -- upconversion; Science -- Periodicals; 505
• DOI: 10.1002/advs.201802157
• Languages: English
• ISSNs: 2198-3844

Abstract

Abstract: Combined phototherapy and immunotherapy demonstrates strong potential in the treatment of metastatic cancers. An upconversion nanoparticle (UCNP) based antigen‐capturing nanoplatform is designed to synergize phototherapies and immunotherapy. In particular, this nanoplatform is constructed via self‐assembly of DSPE‐PEG‐maleimide and indocyanine green (ICG) onto UCNPs, followed by loading of the photosensitizer rose bengal (RB). ICG significantly enhances the RB‐based photodynamic therapy efficiency of UCNP/ICG/RB‐mal upon activation by a near‐infrared (NIR) laser, simultaneously achieving selective photothermal therapy. Most importantly, tumor‐derived protein antigens, arising from phototherapy‐treated tumor cells, can be captured and retained in situ, due to the functionality of maleimide, which further enhance the tumor antigen uptake and presentation by antigen‐presenting cells. The synergized photothermal, photodynamic, and immunological effects using light‐activated UCNP/ICG/RB‐mal induces a tumor‐specific immune response. In the experiments, intratumoral administration of UCNP/ICG/RB‐mal, followed by noninvasive irradiation with an NIR laser, destroys primary tumors and inhibits untreated distant tumors, using a poorly immunogenic, highly metastatic 4T1 mammary tumor model. With the simultaneous use of anti‐CTLA‐4, about 84% of the treated tumor‐bearing mice achieve long‐term survival and 34% of mice develop tumor‐specific immunity. Overall, this antigen‐capturing nanoplatform provides a promising approach for the treatment of metastatic cancers. Abstract : An NIR‐triggered antigen‐capturing nanoplatform is designed to synergize photodynamic, photothermal, and immunotherapy for cancer treatment. The enhanced photothermal/photodynamic effects using the nanoplatform release tumor‐derived protein antigens, which in turn are captured and retained in situ by the nanoplatform. The enhanced uptake and presentation of antigens by antigen‐presenting cells facilitate a tumor‐specific immune response to inhibit tumor metastasis.