Design and Synthesis of Two Oxazine Derivatives Using Several Strategies. (22nd January 2014)

• Record Type: Journal Article
• Authors: Lauro, Figueroa-Valverde; Francisco, Díaz-Cedillo; Marcela, Rosas-Nexticapa; Elodia, García-Cervera; Eduardo, Pool-Gómez; María, López-Ramos; Lenin, Hau-Heredia; Betty, Sarabia-Alcocer
• Other Names: Talele Tanaji Academic Editor.
• Is Part Of: Journal of chemistry. Volume 2014(2014)
• Publication Date: 2014-01-22
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1155/2014/757953
• Languages: English
• ISSNs: 2090-9063

Abstract

Abstract : Several oxazine derivatives have been synthesized; nevertheless, expensive reagents and special conditions are required. Therefore, in this study, two oxazine derivatives (2-chloro-3-{{2-[-(3-chloro-2-oxo-cyclobutyl)-(2, 3-dimethoxy-9, 10-dihydrostrychnid-10-yl)-amino]-ethyl}-[1, 5-dimethyl-4-(1 H -naphtho[1, 2-e][1, 3-oxazin-2-yl)-2-phenyl-2, 3-dihydro-1H-pyrazol-3-yl]-amino}-cyclobutanone and 2-chloro-3-{{2-[(3-chloro-2-oxo-cyclobutyl)-(1, 7, 7-trimethyl-bicyclo[2.2.1]hept-2-yl)-amino]-ethyl}-[1, 5-dimethyl-4-(1 H -naphtho[1, 2-e][1, 3]oxazin-2-yl)-2-phenyl-2, 3-dihydro-1 H -pyrazol-3-yl]-amino}-cyclobutanone) were synthesized using several strategies. The structure of compounds obtained was confirmed by elemental analysis, spectroscopy, and spectrometry data. In conclusion, the methods used offer some advantages such as good yields, simple procedure, low cost, and ease of workup.