Antiproliferative Activity Evaluation of a Series of N-1, 3-Benzothiazol-2-ylbenzamides as Novel Apoptosis Inducers. (21st January 2016)

• Record Type: Journal Article
• Authors: Corbo, Filomena; Carocci, Alessia; Armenise, Domenico; De Laurentis, Nicolino; Laghezza, Antonio; Loiodice, Fulvio; Ancona, Patrizia; Muraglia, Marilena; Pagliarulo, Vincenzo; Franchini, Carlo; Catalano, Alessia
• Other Names: Talele Tanaji Academic Editor.
• Is Part Of: Journal of chemistry. Volume 2016(2016)
• Publication Date: 2016-01-21
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1155/2016/4267564
• Languages: English
• ISSNs: 2090-9063

Abstract

Abstract : A series of N -1, 3-benzothiazol-2-ylbenzamide derivatives were studied for their antiproliferative activity on human liver hepatocellular carcinoma (HepG2) and human breast cancer (MCF-7) cell lines. Most of them were found to show a prominent inhibitory effect on cell growth. Among the most active compounds, 1k emerged for its proapoptotic effect that is particularly evident towards MCF-7 cancer cell lines.