Synthesis of PAMAM Dendrimers Loaded with Mycophenolic Acid to Be Studied as New Potential Immunosuppressants. (5th May 2015)

• Record Type: Journal Article
• Authors: Guazzelli, Lorenzo; D'Andrea, Felicia; Giorgelli, Francesco; Catelani, Giorgio; Panattoni, Alessandra; Luvisi, Andrea
• Other Names: Demonceau Albert Academic Editor.
• Is Part Of: Journal of chemistry. Volume 2015(2015)
• Publication Date: 2015-05-05
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1155/2015/263072
• Languages: English
• ISSNs: 2090-9063

Abstract

Abstract : The terminal N -Boc protected diamino PAMAM7 was condensed (EDC-DMAP) with two units of mycophenolic acid (MPA) giving the N -Boc protected dendron8 in a good yield (76%). The ammonium trifluoroacetate9 was prepared from8 by acid treatment (TFA-THF-H2 O) and was split into two equal parts. The first half was treated with di-2-pyridyl thionocarbonate (DPT) in the presence of Et3 N to give the corresponding isothiocyanate10 . This was reacted with the second half of9 providing the symmetrical dendrimer11 (68% yield), exposing four MPA units around the thioureido-PAMAM core.