Transdermal applications of ethosomes – a detailed review. (3rd April 2019)

• Record Type: Journal Article
• Authors: Nainwal, Nidhi; Jawla, Sunil; Singh, Ranjit; Saharan, Vikas Anand
• Is Part Of: Journal of liposome research. Volume 29:Number 2(2019)
• Page Start: 103
• Page End: 113
• Publication Date: 2019-04-03
• Subjects: Drug delivery applications -- ethosomes -- mechanism of delivery -- stability -- safety; Liposomes -- Periodicals; Liposomes -- Periodicals; 575.57
• DOI: 10.1080/08982104.2018.1517160
• Languages: English
• ISSNs: 0898-2104

Abstract

Abstract: Skin, the largest organ of the body serves as a potential route of drug delivery for local and systemic effects. However, the outermost layer of skin, the stratum corneum (SC) acts as a tough barrier that prevents penetration of hydrophilic and high molecular weight drugs. Ethosomes are a novel phospholipid vesicular carrier containing high ethanol concentrations and offer improved skin permeability and efficient bioavailability due to their structure and composition. This article gives a review of ethosomes including their compositions, types, mechanism of drug delivery, stability, and safety behaviour. This article also provides a detailed overview of drug delivery applications of ethosomes in various diseases.