Direct Incorporation of [11C]CO2 into Asymmetric [11C]Carbonates. (10th December 2018)

• Record Type: Journal Article
• Authors: Haji Dheere, Abdul Karim; Bongarzone, Salvatore; Shakir, Dinah; Gee, Antony
• Other Names: Cheng Zhen Academic Editor.
• Is Part Of: Journal of chemistry. Volume 2018(2018)
• Publication Date: 2018-12-10
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1155/2018/7641304
• Languages: English
• ISSNs: 2090-9063

Abstract

Abstract : A novel carbon-11 radiolabelling methodology for the synthesis of the dialkylcarbonate functional group has been developed. The method uses cyclotron-produced short-lived [ 11 C]CO2 (half-life 20.4 min) directly from the cyclotron target in a one-pot synthesis. Alcohol in the presence of base trapped [ 11 C]CO2 efficiently forming an [ 11 C]alkylcarbonate intermediate that subsequently reacted with an alkylchloride producing the di-substituted [ 11 C]carbonate (34% radiochemical yield, determined by radio-HPLC) in 5 minutes from the end of [ 11 C]CO2 cyclotron delivery.