Efficacy of hypertonic (2.3%) sea water in patients with aspirin-induced chronic rhinosinusitis following endoscopic sinus surgery. (3rd June 2019)

• Record Type: Journal Article
• Authors: Perić, Aleksandar; Kovačević, Sandra Vezmar; Barać, Aleksandra; Gaćeša, Dejan; Perić, Aneta V.; Jožin, Svjetlana Matković
• Is Part Of: Acta oto-laryngologica. Volume 139:Number 6(2019)
• Page Start: 529
• Page End: 535
• Publication Date: 2019-06-03
• Subjects: Aspirin -- nasal polyps -- nasal surgical procedures -- postoperative care -- sinusitis; Otolaryngology -- Periodicals; Ear -- Diseases -- Periodicals; Throat -- Diseases -- Periodicals; Otolaryngology -- Electronic Resources; Otorhinolaryngologic Diseases; 617.8
• DOI: 10.1080/00016489.2019.1605454
• Languages: English
• ISSNs: 0001-6489

Abstract

Abstract: Background: Aspirin-induced chronic rhinosinusitis (CRS) is a severe progressive persistent disease, usually associated with nasal polyps (NPs). Aim/objective: To compare effect of hypertonic (2.3% NaCl) sea water and isotonic 0.9% NaCl on symptoms and endoscopic findings in those patients in the period of 1 month after endoscopic sinus surgery (ESS). Material and methods: This prospective, randomized study included 30 patients with aspirin-induced CRS undergoing ESS. Patients were divided into two groups of 15 subjects and one of the two nasal irrigation solutions was administered in each group. Intensity of 5 symptoms (nasal obstruction, nasal discharge/postnasal drip, facial pain/pressure, headache and trouble sleeping) and endoscopic findings were assessed during the 1st, 7th, 14th, 21st and 28th days after the nasal packs removal. Results: We found significantly lower total symptom score (TSS) during the 7th ( p = .009), 14th ( p = .003), 21st ( p < .001) and the 28th day ( p = .001), lower total endoscopic score (TES) on the 21st ( p = .002) and 28th day ( p = .001), lower nasal obstruction, facial pain/pressure, headache and trouble sleeping, and lower nasal mucosal edema, nasal secretion and nasal crusting in patients treated by hypertonic sea water. Conclusion and significance: Hypertonic sea water should be recommended douching solution in the early postoperative care of patients with aspirin-induced CRS.