Two new benzophenones and one new natural amide alkaloid isolated from a mangrove-derived Fungus Penicillium citrinum. Issue 8 (18th April 2019)

• Record Type: Journal Article
• Authors: Zheng, Cai-Juan; Liao, Hai-Xia; Mei, Rong-Qing; Huang, Guo-Lei; Yang, Lu-Jia; Zhou, Xue-Ming; Shao, Tai-Ming; Chen, Guang-Ying; Wang, Chang-Yun
• Is Part Of: Natural product research. Volume 33:Issue 8(2019)
• Page Start: 1127
• Page End: 1134
• Publication Date: 2019-04-18
• Subjects: Penicillium citrinum -- penibenzophenone -- amide alkaloid -- cytotoxic activity -- antibacterial activity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2018.1460832
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Two new compounds penibenzophenones A-B (1–2 ), and the synthetic α, β -unsaturated amide alkaloid ( E )-tert-butyl(3-cinnamamidopropyl)carbamate (4 ), newly identified as a natural product, alone with three known ones (3, 5–6 ) were isolated from the EtOAc extract of the endophytic fungus Penicillium citrinum HL-5126 isolated from the mangrove Bruguiera sexangula var. rhynchopetala collected in the South China Sea. Compound1 was a chlorinated benzophenone. The structures of1–6 were elucidated by extensive NMR spectral interpretation, MS data and X-ray analysis. The new compound2 displayed cytotoxic activity against human A549 cell lines with an IC50 value of 15.7 μg/mL, and1 showed antibacterial activity against Staphylococcus aureus with a MIC value of 20 μg/mL. Abstract :