One-pot synthesized Cu/Au/Pt trimetallic nanoparticles as a novel enzyme mimic for biosensing applications. Issue 26 (14th May 2019)

• Record Type: Journal Article
• Authors: Wu, Pian; Ding, Ping; Ye, Xiaosheng; Li, Lei; He, Xiaoxiao; Wang, Kemin
• Is Part Of: RSC advances. Volume 9:Issue 26(2019)
• Page Start: 14982
• Page End: 14989
• Publication Date: 2019-05-14
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c9ra00603f
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : A class of novel Cu/Au/Pt TNPs with enhanced peroxidase-like activity was developed and used as enzyme mimics for biosensing. Abstract : Multimetallic nanomaterials have aroused special attention owing to the unique characteristics of chemical, optical and enhanced enzyme mimetic capabilities resulting from the synergistic effect of different metal elements. In this work, we present a facile, gentle, fast and one-pot method for preparing Cu/Au/Pt trimetallic nanoparticles (TNPs), which possess intrinsic and enhanced peroxidase-like activity as well as excellent stability, sustainable catalytic activity, and robustness to harsh environments. Kinetic analysis indicated that Cu/Au/Pt TNPs exhibited strong affinities with H2 O2 and 3, 3, 5, 5-tetramethylbenzidine (TMB) as the substrates. To investigate the feasibility of Cu/Au/Pt TNPs-based strategy in biological analysis, H2 O2 was chosen as a model analyte and a sensitive and specific detection for H2 O2 was acquired with a detection limit of 17 nM. By coupling with glucose oxidase (GOD), this assay could also achieve a sensitive and selective detection of glucose with a detection limit of 33 μM, indicating the versatility of the method. In view of the potential combination with diverse enzyme-related reactions, the Cu/Au/Pt TNPs-based strategy is promising as a universal platform for biosensors.