Ruthenium-catalyzed ortho-selective CAr–H amination of heteroaryl arenes with di-tert-butyldiaziridinone. Issue 38 (24th April 2019)

• Record Type: Journal Article
• Authors: Gou, Xue-Ya; Li, Yuke; Wang, Xin-Gang; Liu, Hong-Chao; Zhang, Bo-Sheng; Zhao, Jia-Hui; Zhou, Zhao-Zhao; Liang, Yong-Min
• Is Part Of: Chemical communications. Volume 55:Issue 38(2019)
• Page Start: 5487
• Page End: 5490
• Publication Date: 2019-04-24
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c9cc02499a
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Application of an oxidative amination reagent (di- tert -butyldiaziridinone) to the Ru3 (CO)12 -catalyzed ortho -selective CAr –H amination reaction is described. Abstract : Application of an oxidative amination reagent (di- tert -butyldiaziridinone) to the Ru3 (CO)12 -catalyzed ortho -selective CAr –H amination reaction is described. This strategy shows good functional group compatibility with various phenyl-substituted N-heterocycles, including biologically active substrates, thus providing synthetic potential for this methodology. Mechanistic studies showed that the reaction process involves an octahedral ruthenium species, and the carbon monoxide ligand plays a crucial role in the C–H activation.