A perylenediimide-based nanocarrier monitors curcumin release with an "off–on" fluorescence switch. Issue 20 (24th April 2019)

• Record Type: Journal Article
• Authors: Cheng, Wenyu; Chen, Hongtao; Ji, Chendong; Yang, Ru; Yin, Meizhen
• Is Part Of: Polymer chemistry. Volume 10:Issue 20(2019)
• Page Start: 2551
• Page End: 2558
• Publication Date: 2019-04-24
• Subjects: Polymers -- Periodicals; Macromolecules -- Periodicals; Polymerization -- Periodicals; 547.705
• DOI: 10.1039/c9py00132h
• Languages: English
• ISSNs: 1759-9954

Abstract

Abstract : A perylenediimide-based nanocarrier (PPL-B) is constructed and used for monitoring curcumin release through an "off–on" fluorescence switch. Abstract : Perylenediimide-cored (PDI-cored) polymers have been widely applied as fluorescent drug carriers due to their high fluorescence quantum yield and outstanding chemical/photophysical stability. However, most of these delivery systems lack detailed drug delivery specifics, especially when and where the drug is released. In this study, a PDI-based nanocarrier (PPL-B) is constructed and applied to monitor curcumin release with an "off–on" fluorescence switch. The star-shaped drug carrier has an amphiphilic structure with fluorescent PDI as the core and poly(amino acid) as the shell, which is suitable for drug delivery. A model drug curcumin is loaded to PPL-B and quenches its fluorescence significantly through photo-induced electron transfer (PET). Upon curcumin release, the fluorescence of PPL-B achieves an "off–on" switch as a result of PET interruption. In light of this, curcumin release is successfully monitored by CUR@PPL-B at the cellular level. This PDI-based nanocarrier for drug release monitoring with a PET mechanism shows great potential in the drug delivery field.