Synthesis of functionalized tetrahydrofuran derivatives from 2, 5-dimethylfuran through cascade reactions. Issue 10 (7th May 2019)

• Record Type: Journal Article
• Authors: Li, J.; Muller, E.; Pera-Titus, M.; Jérôme, F.; De Oliveira Vigier, K.
• Is Part Of: Green chemistry. Volume 21:Issue 10(2019)
• Page Start: 2601
• Page End: 2609
• Publication Date: 2019-05-07
• Subjects: Environmental chemistry -- Industrial applications -- Periodicals; Environmental management -- Periodicals; 660
• DOI: 10.1039/c9gc01060b
• Languages: English
• ISSNs: 1463-9262

Abstract

Abstract : Convenient catalytic route for selectively functionalizing the methyl group of an important bio-based furanic derivatives (DMF). Abstract : A three-step strategy is proposed for the functionalization of the methyl group of 2, 5-dimethylfuran, encompassing the ring opening of 2, 5-dimethylfuran to 2, 5-hexanedione, its further aldol condensation with aldehydes, and hydrogenation–cyclization of the condensation intermediate to generate alkylated tetrahydrofuran. Active and selective catalysts could be identified for the aldol condensation and hydrogenation–cyclization reactions.