A Benzochalcone Derivative, (E)-1-(2-hydroxy-6-methoxyphenyl)-3-(naphthalen-2-yl)prop-2-en-1-one (DK-512), Inhibits Tumor Invasion through Inhibition of the TNFα-Induced NF-κB/MMP-9 Axis in MDA-MB-231 Breast Cancer Cells. (11th October 2016)

• Record Type: Journal Article
• Authors: Shin, Soon Young; Kim, Chang Gun; Ahn, Seunghyun; Jung, You Jung; Koh, Dongsoo; Lee, Young Han; Lim, Yoongho
• Other Names: Campos Joaquin Academic Editor.
• Is Part Of: Journal of chemistry. Volume 2016(2016)
• Publication Date: 2016-10-11
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1155/2016/4921717
• Languages: English
• ISSNs: 2090-9063

Abstract

Abstract : Tumor invasion is a critical step in tumor metastasis. In this study, we synthesized a novel benzochalcone derivative, ( E )-1-(2-hydroxy-6-methoxyphenyl)-3-(naphthalen-2-yl) prop-2-en-1-one (DK-512), and characterized its effects on tumor invasion and its mechanism of action. We found that DK-512 strongly inhibited invasion of metastatic MDA-MB-231 breast cancer cells as revealed by a three-dimensional spheroid culture system. Tumor invasion and metastasis require disruption of the extracellular matrix. Matrix metalloproteinase-9 (MMP-9) is an endopeptidase that degrades extracellular matrix components. DK-512 significantly reduced tumor necrosis factor- α - (TNF α -) induced MMP-9 mRNA expression through the inhibition of RelA nuclear factor- (NF-) κ B transcription factor. As our study was assessed in vitro, further works about in vivo efficacy of DK-512 are needed to gain further insights into whether DK-512 could be utilized as a scaffold for the development of antimetastatic agents for breast cancer.