Fabrication of a Porous Metal-Organic Framework with Polar Channels for 5-Fu Delivery and Inhibiting Human Osteosarcoma Cells. (25th July 2018)

• Record Type: Journal Article
• Authors: Zhao, Li-Chun; Tang, Mei; Zhang, Qian-Hua; Hu, Zhi-Yi; Gao, Hong-Wei; Liao, Xia-Yun; Wang, Gang; Leng, Jing
• Other Names: Carvalho Maria F. Academic Editor.
• Is Part Of: Journal of chemistry. Volume 2018(2018)
• Publication Date: 2018-07-25
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1155/2018/1523154
• Languages: English
• ISSNs: 2090-9063

Abstract

Abstract : As an emerging kind of crystalline material, the metal-organic framework (MOF) has shown great promise in the biomedical domains such as drug storage and delivery. In this study, a new porous MOF, [[Dy2 (H2 O)3 (SDBA)3 ](DMA)6 ] (1, H2 SDBA = 4, 4′-sulfonyldibenzoic acid, DMA = N, N -dimethylacetamide (C4 H9 NO)), with uncoordinated O donor sites has been fabricated using a bent polycarboxylic acid organic linker under the solvothermal condition. The structure of the obtained crystalline product has been fully determined by the X-ray single-crystal diffraction, TGA, elemental analysis, XRD, and the gas sorption measurement. Due to the suitable window size and polar atom functionalized 1D channels, the activated1 (1a ) compound was used for the anticancer drug 5-fluorouracil (5-Fu, C4 H3 FN2 O2 ) loading by a simple impregnation method. A moderate drug loading and pH-dependent drug-release behavior could be observed for1a . Furthermore, as indicated by the MTT assay, this drug/MOF composite shows low toxicity toward the human normal cells and demonstrates obvious anticancer activity against the human osteosarcoma cell line MG63.